Belle II Technical Design Report

The Belle detector at the KEKB electron-positron collider has collected almost 1 billion Y(4S) events in its decade of operation. Super-KEKB, an upgrade of KEKB is under construction, to increase the luminosity by two orders of magnitude during a three-year shutdown, with an ultimate goal of 8E35 /cm^2 /s luminosity. To exploit the increased luminosity, an upgrade of the Belle detector has been proposed. A new international collaboration Belle-II, is being formed. The Technical Design Report presents physics motivation, basic methods of the accelerator upgrade, as well as key improvements of the detector.Comment: Edited by: Z. Dole\v{z}al and S. Un

Atomic Energy Commission Reports

Report describing a 300-Mw(e) Supercritical Pressure Power Reactor's facilities, physics, economics, and problems encountered during its development. Appendix begins on page 103

The relationship between hemoglobin and [Formula: see text]: A systematic review and meta-analysis.

ObjectiveThere is widespread agreement about the key role of hemoglobin for oxygen transport. Both observational and interventional studies have examined the relationship between hemoglobin levels and maximal oxygen uptake ([Formula: see text]) in humans. However, there exists considerable variability in the scientific literature regarding the potential relationship between hemoglobin and [Formula: see text]. Thus, we aimed to provide a comprehensive analysis of the diverse literature and examine the relationship between hemoglobin levels (hemoglobin concentration and mass) and [Formula: see text] (absolute and relative [Formula: see text]) among both observational and interventional studies.MethodsA systematic search was performed on December 6th, 2021. The study procedures and reporting of findings followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Article selection and data abstraction were performed in duplicate by two independent reviewers. Primary outcomes were hemoglobin levels and [Formula: see text] values (absolute and relative). For observational studies, meta-regression models were performed to examine the relationship between hemoglobin levels and [Formula: see text] values. For interventional studies, meta-analysis models were performed to determine the change in [Formula: see text] values (standard paired difference) associated with interventions designed to modify hemoglobin levels or [Formula: see text]. Meta-regression models were then performed to determine the relationship between a change in hemoglobin levels and the change in [Formula: see text] values.ResultsData from 384 studies (226 observational studies and 158 interventional studies) were examined. For observational data, there was a positive association between absolute [Formula: see text] and hemoglobin levels (hemoglobin concentration, hemoglobin mass, and hematocrit (PConclusionThese findings suggest that [Formula: see text] values are closely associated with hemoglobin levels among both observational and interventional studies. Although our findings suggest a lack of sex differences in these relationships, there were limited studies incorporating females or stratifying results by biological sex

Risk of bias among interventional articles.

ObjectiveThere is widespread agreement about the key role of hemoglobin for oxygen transport. Both observational and interventional studies have examined the relationship between hemoglobin levels and maximal oxygen uptake () in humans. However, there exists considerable variability in the scientific literature regarding the potential relationship between hemoglobin and . Thus, we aimed to provide a comprehensive analysis of the diverse literature and examine the relationship between hemoglobin levels (hemoglobin concentration and mass) and (absolute and relative ) among both observational and interventional studies.MethodsA systematic search was performed on December 6th, 2021. The study procedures and reporting of findings followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Article selection and data abstraction were performed in duplicate by two independent reviewers. Primary outcomes were hemoglobin levels and values (absolute and relative). For observational studies, meta-regression models were performed to examine the relationship between hemoglobin levels and values. For interventional studies, meta-analysis models were performed to determine the change in values (standard paired difference) associated with interventions designed to modify hemoglobin levels or . Meta-regression models were then performed to determine the relationship between a change in hemoglobin levels and the change in values.ResultsData from 384 studies (226 observational studies and 158 interventional studies) were examined. For observational data, there was a positive association between absolute and hemoglobin levels (hemoglobin concentration, hemoglobin mass, and hematocrit (PPP = 0.006)).ConclusionThese findings suggest that values are closely associated with hemoglobin levels among both observational and interventional studies. Although our findings suggest a lack of sex differences in these relationships, there were limited studies incorporating females or stratifying results by biological sex.</div

PRISMA flow diagram.

Flow diagram displaying the selection of articles through different phases of the systematic review, and categorization of included articles.</p

Risk of bias among observational articles.

ObjectiveThere is widespread agreement about the key role of hemoglobin for oxygen transport. Both observational and interventional studies have examined the relationship between hemoglobin levels and maximal oxygen uptake () in humans. However, there exists considerable variability in the scientific literature regarding the potential relationship between hemoglobin and . Thus, we aimed to provide a comprehensive analysis of the diverse literature and examine the relationship between hemoglobin levels (hemoglobin concentration and mass) and (absolute and relative ) among both observational and interventional studies.MethodsA systematic search was performed on December 6th, 2021. The study procedures and reporting of findings followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Article selection and data abstraction were performed in duplicate by two independent reviewers. Primary outcomes were hemoglobin levels and values (absolute and relative). For observational studies, meta-regression models were performed to examine the relationship between hemoglobin levels and values. For interventional studies, meta-analysis models were performed to determine the change in values (standard paired difference) associated with interventions designed to modify hemoglobin levels or . Meta-regression models were then performed to determine the relationship between a change in hemoglobin levels and the change in values.ResultsData from 384 studies (226 observational studies and 158 interventional studies) were examined. For observational data, there was a positive association between absolute and hemoglobin levels (hemoglobin concentration, hemoglobin mass, and hematocrit (PPP = 0.006)).ConclusionThese findings suggest that values are closely associated with hemoglobin levels among both observational and interventional studies. Although our findings suggest a lack of sex differences in these relationships, there were limited studies incorporating females or stratifying results by biological sex.</div

Association between hemoglobin concentration and maximal oxygen uptake ().

Bubble plot and meta-regression displaying the positive association between hemoglobin concentration and both absolute (A) and relative (B). Data for males are represented as purple bubbles, data for females are represented as green bubbles with plus sign symbols, and data for studies presenting males and females pooled (mixed) are represented as black bubbles with middle dot symbols. Each bubble represents a group from a single study and the size of bubbles represents the number of participants within the group. The solid line indicates the meta-regression line, and the dashed lines indicate the 95% prediction interval associated with the meta-regression. (DOCX)</p